Scientists make “sugar bug” drug for bowel disease
London, August 21: A genetically modified bacterium that turns into a drug-delivery vehicle in the presence of a type of sugar may offer a new way to treat bowel disease, British scientists said on Friday.
The new approach uses an engineered form of Bacteroides ovatus to deliver a human growth factor called KGF-2 directly to damaged cells in the gut — but the process is only activated in the presence of xylan, a sugar that is rare in normal diet.