Washington, December 07: European scientists have found that asthmatic smokers could “reverse” some of the damage done to their lungs just by putting down cigarette.
According to researchers at the University of Groningen, Netherlands, smoking asthmatics can reverse some of the damage to their lungs that exacerbates asthmatic symptoms just by quitting smoking, the American Journal of Respiratory and Critical Care Medicine reported.
“We found that exposure to cigarette smoke appears to increase the thickness of the epithelium, or lining, of the airways in the lung,” lead author Martine Broekema said.
Broekema said, “This may be the underlying cause of the fact that smoking asthma patients experience more asthma symptoms, such as shortness of breath and phlegm production, compared to non-smoking asthma patients”.
In addition to the changes in the epithelial thickness, Broekema found distinct differences between the current smokers and the ex- and non-smokers.
“Furthermore, our data suggest that smoking cessation can reverse the thickening of the lining of the airways,” she added.
The team examined patients with asthma who were assessed each for the severity of their asthma and allergy, given questionnaires to determine the extent of their smoke-induced symptoms, and then underwent bronchial biopsies.
Of the total of 147 patients, 66 never smoked, 46 were ex-smokers and 35 were current smokers.
Broekema said, “In addition to the epithelial thickening, we found that cigarette smoke negatively affects levels of exhaled nitric oxide, making it an unreliable indicator of asthma severity in smokers”.
“These pathological findings were associated with the severity of phlegm production reported by the asthma patients, suggesting a causal relationship between the two,” she added.
Smoking asthmatics also showed a distinct inflammatory profile in their lungs compared to never-smoking asthmatics, with a lower number of eosinophils and higher number of mast cells, the study said.
To determine the role of exposure length on asthmatic lungs, the scientists divided the ex-smokers into two groups: those with fewer than the median 3.4 pack-year exposure and those with more than 3.4 pack-years.
Interestingly, while they expected to find evidence of a dose-response effect between smoking and epithelial remodeling, no such association was apparent between the number of pack-years or duration of smoking cessation and epithelial remodeling.
“To our surprise, these two sub-groups of ex-smokers showed no difference in any outcome measure. These sub-analyses indicate that the amount of smoke exposure in the past does not influence our outcome measures,” said Broekema.
She added, “This study shows again how important smoking cessation is for pulmonary health, and this appears to be especially true for asthmatic patients. The good news is that quitting appears to have a measurable benefit in these individuals.”
–PTI