How can a Gene be edited? Basic information

Gene Editing is also called as ‘Genome Editing.’

In this technique, it involves the addition, insertion or removal of DNA at a specific site in the genome of an organism.

DNA

This is achieved by using engineered nucleases, also known as molecular scissors.

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Genome Editing can be done by using engineered nucleases such as:

• CRISPR-Cas9
• Viral systems such as rAAV (Recombinant Adeno-Associated Virus)
• Transposons
• ZFNs or TALENs

Applications of Gene Editing

• Eradication of diseases
• Targeted gene modification in plants such as to produce pest-resistant, drought resistant plants
• Gene therapy
• Correction of disease causing mutations